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Low back pain is the leading cause of disability worldwide. Exercise helps alleviate back pain, which modality, Progressive aerobic or progressive resistance training is superior? Wewege et al.1 conducted a meta-analysis to compare the differences between progressive aerobic training (PAT) and progressive resistance training (PRT) on the treatment of chronic non-specific low back pain (CNSLBP). […]

Trott et al.1 conducted a meta-analysis to study the association between total physical activity (PA) levels and academic performance in adults. Only 6 of the 36 studies included were found to be appropriately homogeneous to be included in the meta-analysis. This meta-analysis found a signficiant association between physical activity and academic performance (objective measures: GPA,

An interesting randomized control trial (RCT) was published by O’Sullivan et al in the journal of Psychiatry Research and found that two 25 minute resistance exercise training (RET) sessions a week for 8 weeks resulted in significant decreases in reported depressive symptoms when compared to a wait-list control group. Compared to the effect size of

A recent study1 published in JAMA by Stamatakis et al. set out to answer this question. They conducted a prospective cohort analysis of 22,398 people from the UK biobank accelerometry subsample. They found that compared to those who did not engage in vigorous intermittent lifestyle physical activity (VILPA), just 3.4-3.6 minutes of VILPA was correlated

Mitochondrial health is key to health and disease Skeletal muscle plays an instrumental role in mitochondrial function in both health and disease as it is the most bioenergetically active organ with the highest mitochondrial content. mitochondrial dysfunction has traditionally been linked to type 2 diabetes, it is also a hallmark of multiple diseases, including cardiovascular

Skeletal muscle lipid paradox – “A significant histological finding pertaining to skeletal fat metabolism occurs in physically fit individuals as well as in individuals with T2D, where both populations show an accumulation of intramuscular triglycerides. as both physically fit individuals as well as individuals with T2D are characterized by the presence of a “lipid droplet”

Today I bring to you part 8 of my notes on this review paper by Inigo San-Millan. Here are my quick takeaways from the section pertaining to type 2 diabetes. This study mentions that recent studies demonstrate that around 52% of people in America are either type 2 diabetic or pre-diabetic. You guessed it, skeletal

Part 6, this should be fun. Interestingly, mitochondria are the main producers of reactive oxygen species (ROS). ROS are necessary and involved in maintaining the following: With almost anything in biology, there is an optimal range of ROS concentration. Excess ROS production can be countered with antioxidants such as: If ROS production exceeds antioxidant capacity

Part 4. Let’s do this. Something to quickly note from Andy Galpin’s lactate performance lecture. When drinking alcohol you metabolize ethanol with anaerobic glycolysis. This downregulates fat metabolism. Normally the fat stored in the liver would be metabolized, but since you have placed ethanol ahead of it in the metabolism cue, liver fat accumulates. When

Here we go! Part 3 of this review paper written by Inigo San-Millan. This post will explore some of the bioenergetics of mitochondria. Mitochondria burn (oxidize) energy from macronutrients through oxidative phosphorylation that occurs in the Krebs cycle. Mitochondria oxidize all major substrates derived from macronutrients. Mitochondria oxidizes pyruvate from carbohydrates, fatty acids derived from