Today I bring to you part 8 of my notes on this review paper by Inigo San-Millan. Here are my quick takeaways from the section pertaining to type 2 diabetes.

This study mentions that recent studies demonstrate that around 52% of people in America are either type 2 diabetic or pre-diabetic. You guessed it, skeletal muscle mitochondria appears to be the culprit. It has been known that those with type 2 diabetes have decreased amounts of mitochondrial content, mitochondrial DNA, transcriptional factors and genes and overall mitochondrial function in skeletal muscle.

It is proposed that skeletal muscle insulin resistance is the primary mechanistic event involved in the development of type 2 diabetes. This shouldn’t be surprising because skeletal muscle is the tissue with the highest uptake of glucose.

Until next time. Thank you for reading.

San-Millán I. The Key Role of Mitochondrial Function in Health and Disease. Antioxidants. 2023; 12(4):782. https://doi.org/10.3390/antiox12040782